More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers. For more than 20 ...

A publication from Acta Pharmaceutica Sinica B discusses the structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Receptor-interacting serine/threonine-protein ...

The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory pathways that have ...

Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...

Protein kinases, including p38α, have therefore been heavily studied. The first protein kinase structure was solved 30 years ago – a landmark in the field – and many more structures have followed, ...

The breakthrough came on molecular biologist Christopher Garcia’s birthday. For more than 20 years, his team and others around the world had been chasing an elusive quarry – the 3D structure of a ...