Why some cancer therapies don't work for all patients: A tumor backup survival pathway

Drugs that block enzymes called tyrosine kinases are among the most effective targeted therapies for cancer. However, they ...
ascopubs.org

Clinical Activity of Mitogen-Activated Protein Kinase Inhibitors in Patients With MAP2K1 (MEK1)-Mutated Metastatic Cancers

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...
Nature

Mitogen-Activated Protein Kinase Signaling Pathways and Inhibitors

Mitogen-Activated Protein Kinase (MAPK) signalling cascades are fundamental to the regulation of numerous cellular processes, including stress response, inflammation, cell cycle control and apoptosis.
News Medical

Scientists map how cinnamon’s bioactives interact with cancer signaling

Laboratory studies suggest cinnamon’s bioactive compounds can alter key cancer-related signaling pathways, but researchers caution that human trials are essential before any preventive or therapeutic ...
The American Journal of Managed Care

5 FDA Developments From February: Kinase Inhibitors, GLP-1s, and a New Approval Pathway

Zongertinib gained accelerated approval for unresectable/metastatic HER2 kinase-domain–mutant nonsquamous NSCLC, with 76% ORR and DOR ≥12 months in 44%. AMPLIFY ...