Transcription factors (TFs) are proteins that regulate the gene expression programs and the identity of each cell by encountering numerous binding partners in the nucleus to turn transcription on or ...

In biology classrooms, we often learn that genes are transcribed into mRNA, which is then translated into proteins—a tidy, linear process. But gene expression in living cells is far more intricate, ...

The glucocorticoid receptor (GR) is a ligand-activated transcription factor that regulates a suite of genes through direct binding of GR to specific DNA promoter elements. GR also interacts with RNA, ...