The turnover of integrin receptors is critical for cell migration and adhesion dynamics. Here we find that force development at integrins regulates adaptor protein recruitment and endocytosis. Using ...

In a recent study published in the Proceedings of the National Academy of Sciences Journal, researchers examined the therapeutic effects of targeting integrins for treating Amyotrophic lateral ...

A new review links three forces shaping osteoarthritis: mechanical stress, integrin signaling, and integrin endocytosis. The ...

Inflammation drives TGFβ1 activation via the αvβ6 integrin-mechanotransduction pathway in human skin. Transforming growth factor β (TGFβ) is a critical regulator of skin home ...

Integrins are heterodimer transmembrane receptors for the extracellular matrix composed of an alpha and beta subunit. Natural integrin ligands include laminin, fibronectin, and vitronectin, but they ...

Johns Hopkins University biologists have found that a protein that plays a key role in the lives of stem cells can bolster the growth of damaged muscle tissue, a step that could potentially contribute ...

Integrins are heterodimeric, transmembrane receptors that function in cell adhesion and signalling. They are central to many disease states, including cancer, thrombosis, multiple sclerosis and ...

Scientists from the Mechanobiology Institute, Singapore (MBI) at the National University of Singapore have discovered the universal building blocks that cells use to form initial connections with the ...