The endoderm layer destined to be primitive gut is a mosaic of earlier visceral endoderm and definitive endoderm that arises later, during gastrulation. Live imaging now reveals that in mouse embryos, ...

Pluripotent stem cells, created from human skin or mouse ear tissue, are shown here becoming endoderm cells. The endoderm is one of the three primary germ layers that ultimately contribute to the ...

Foxa transcription factors help endow the competence to activate liver genes in development by binding to regulatory sequences in precursor endoderm and opening a local domain of chromatin. Fibroblast ...

Scientists revise the current textbook knowledge about gastrulation, the formation of the basic body plan during embryonic development. Their study in mice has implications for cell replacement ...

Summary Scientists in the Sloan Kettering Institute have combined powerful laboratory and computational techniques to analyze the earliest moments of mouse development. The results could help explain ...

How do cells turn into organs? During embryonic development, three germ layers form, known as the endoderm, the mesoderm, and the ectoderm. These germ layers give rise to different parts of the ...

Molecular gradients have been established as a key driving force for cellular organization in the formation of early structures during embryonic development. A new live imaging technique has been ...