Our cells move energy and matter to the places it is needed. But how do they do this in real time, and seen from the perspective of a single molecule? Scientists have successfully uncovered new basic ...

The enzyme is the calcium-pumping Ca2+-ATPase - an ion pump protein that maintains a concentration of calcium inside the cell, which is about 20,000 times lower than outside. Only, it does not pump ...

Figure 1: Structures of calcium pump before (left) and after (right) it has transported ions into the sarcoplasmic reticulum (A, N, P: three cytoplasmic domains; TM ...

Cells have to invest a lot of energy to maintain this concentration gradient, especially when it comes to getting rid of calcium. 'It's like being on a rush-hour train in a city like Tokyo. When the ...

Parasitic wasps switch off the immune systems of fruit flies by draining calcium from the flies' blood cells, a finding that offers new insight into how pathogens break through a host's defenses.

High-speed pumps: Cells use high-speed pumps to pump calcium ions out of their interior. A team has created the first comprehensive transport model of plasma membrane CaATPase (PMCA) to study calcium ...

Boston, MA - The improvement of intracellular calcium cycling, through overexpression of the sarcoplasmic reticulum CA 2+ ATPase pump (SERCA2a), reduces arrhythmias and restores contractile function ...

A key abnormality in heart failure is defective handling of calcium ions by cardiomyocytes. In the healthy heart, the action potential leads to an increase in the level of intracellular calcium (and ...

We evaluated a family in which five siblings were affected by autosomal recessive sensorineural hearing loss. Despite the presumably shared cause of the disorder, there were clinically significant ...